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- Title
ANALYTICAL DETERMINATION FOR CHLORPROTHIXENE.HCL DRUG IN PURE FORM AND MEDICINAL TABLETS BY SPECTROPHOTOMETRIC DERIVATIVES.
- Authors
Sayhood, Aayad Ammar; Hussein, Bayan Jabr; Halboos, Mohanad Hazim
- Abstract
Quantitative measurement, easy, accurate, and reproductive analysis of chlorprothixene.HCl medications (COT) using one of chemometrics method, the spectrophotometric derivatives method of zero (D0), first (D1) and second (D2) order. These suggested methods had been used to determine the (COT) between the range (0.4-3) µg.ml-1, 196.6 and 258.4 nm for 0th order; in (D1) range at 215.8, 247.2 and 268.4 nm; and in (D2) range derivative spectrophotometry at 223.2 and 257.4 nm, respectively. The precise and accurate results of the methods employed have been calculated and are very satisfactory. The limit of detection was estimated in this study, and it ranged between (0.0531-0.0611) µg.ml-1; As for the limit of quantification, it ranged between (0.1776-0.2044) µg.mL-1. This method has been applied to some medicinal doses consisting of this drug (COT), and the results have been impressive.
- Publication
Systematic Reviews in Pharmacy, 2020, Vol 11, Issue 12, p1478
- ISSN
0975-8453
- Publication type
Academic Journal