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- Title
Quercetin- A Natural Antioxidant From Onion May Be Beneficial In The Management Of Osteoporosis.
- Authors
Ismail, Faiza; Asif, Naiyer; Mahdi, Abbas Ali; Islam, Najmul
- Abstract
Background: Bone is a living rigid connective tissue. The main bone degrading disease is osteoporosis that involves the silent decrease in bone strength, accompanied by fragile bone leading to fractures. ROS and TNF-α levels when starts augmenting each other levels synergistically, leads to an increase in bone markers and accelerated osteoclasts activity and hence osteoporosis. Methods: Effects of quercetin was evaluated in the management of osteoporosis by employing cell culture study, ELISA and determination of GPx activity as well as GSH assay. Elevated levels of ROS were arrested by natural antioxidant quercetin, which in turn controls osteoporosis. Results: We report the augmented levels of TNF-α mRNA expression in osteoporosis patients which are in accordance to our earlier reports. Quercetin decreased osteoclasts differentiation (p<0.001). Also, at both the gene and protein levels, the levels of TNF-α were also found to be reduced. The results show the suppression in TNF-α mRNA expression with 20- 25μg/ml of quercetin in mononuclear cells of patients with osteoporosis. Similar observations at the protein level substantiated the above data. Furthermore, we observed the antioxidant induced amelioration in GPx activity and GSH levels coupled with down regulation of TNF-α in cells of osteoporotic patients, thereby, exhibiting the possible chemo preventive property of quercetin in osteoporosis. Conclusion: Thus we may hope and conclude that the side effects of various drugs and therapies involved in osteoporosis may be overcome by the use of this natural antioxidant ie. Quercetin.
- Publication
National Journal of Integrated Research in Medicine, 2017, Vol 8, Issue 2, p110
- ISSN
2230-9969
- Publication type
Academic Journal