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- Title
Comparison of High Molecular Weight Beta Trace Protein and Low Molecular Weight Beta Trace Protein for the Assessment of Kidney Function in Patients with Chronic Kidney Disease.
- Authors
Mohammed, Mudher Kidher; Hamza, Amer; Ewadh, Mufeed Jalil
- Abstract
Background: Chronic kidney disease (CKD) can be defined as either decreased kidney function (GFR < 60ml/min/1.73m²) or persistent kidney damage (indicated by markers of kidney damage) for 3 or more months. BTP is a monomeric glycoprotein with 168 amino acids and a molecular mass variation. Low beta trace protein isoform (L-BTP), the smaller “brain” origin isoforms, predominate in the CSF; whereas, high beta trace protein isoform (H-BTP), the larger “plasma” type glycoforms, predominate in serum and urine. These multiple isoforms certainly have implications for BTP measurement. Aim of Study: Current study was aimed to compare the clinical usefulness of serum levels of H-BTP isoform for the detection of renal dysfunction in patients with chronic kidney disease (CKD) and making a comparison with levels of L-BTP. Method: The study included 150 patients divided into three groups with a wide range of renal dysfunction that encompassed CKD stages from (I-IV). Results: The obtained data showed that H-BTP was highly correlated (Pearson test) with measured GFR (mGFR) (r= 0.86) in logarithmic linear model, and correlated with L-BTP (r= 0.209). The results of this study showed that H-BTP had a significant higher concentration and strongest correlation with mGFR in comparison with L-BTP isoform. Conclusion: H-BTP (and not the L-BTP isoform of brain origin) may be a useful and reliable serum marker for identifying the magnitude of renal dysfunction in patients with CKD and may have its place besides serum cystatin C and creatinine as an alternative endogenous GFR marker.
- Publication
Indian Journal of Public Health Research & Development, 2019, Vol 10, Issue 6, p816
- ISSN
0976-0245
- Publication type
Academic Journal
- DOI
10.5958/0976-5506.2019.01380.9