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- Title
INVESTIGATION OF SIRT-1 ACTIVATOR IN INTRACEREBROPEDUNCLE ETHIDIUM BROMIDE INDUCED EXPERIMENTAL MODEL OF MULTIPLE SCLEROSIS IN RATS.
- Authors
Nidhi, Sharma; Sidharth, Mehan
- Abstract
Multiple sclerosis is an idiopathic, immune mediated process and also called upper motor neuron disorder in which demyelination in neurons occurs in specific regions of brain (i.e. cerebrum, cerebellum, brain stem, spinal cord and optic nerves). In most of the cases 20-40 age group peoples are more prone especially females. It's a globally well-known disease but in India, approximately 2.5lakh peoples are suffering from multiple sclerosis according to MSSI. The main causes of Multiple sclerosis are bacteria (borelia buradoferri), viruses (Episten barr virus, human herpes virus), genetic disorder (6p21, human leucocyte antigen), chemicals exposure(ethidium bromide, pesticides, paints). The sign & symptoms observed in multiple sclerosis patients are memory and cognitive dysfunctions, posture imbalance, vertigo, impaired speech, fatigue. There is limited target based approach for the prevention of pathological hallmark of multiple sclerosis. SIRT-1 is implicated in pathogenesis of neurodegenerative disease. In this we have validate &established an animal model by using ethidium bromide toxin for multiple sclerosis and in that model we hypothesize that SIRT-1 activator, and determine the involvement of SIRT-1 pathway in multiple sclerosis.
- Publication
International Journal of Pharmacy & Life Sciences, 2019, Vol 10, Issue 6, p61
- ISSN
0976-7126
- Publication type
Academic Journal