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- Title
Formulation and Evaluation of mouth dissolving film of Carbamazepine Vishwas Hardiya*and Monika Mann.
- Authors
Hardiya, Vishwas; Mann, Monika
- Abstract
The current approaches in novel drug delivery system main aims to achieve enhanced efficacy and safety of drug molecule by formulating a convenient dosage form for administration and to achieve enhanced patient compliance. One such approach is Oral Films. The present study was an attempt to develop MDF for Carbamazepine, for the prevention of complications of cardiovascular disease. The main interest in such a dosage form was to avoid extensive first pass metabolism, degradation in stomach and for prolonged effect or sustained release profile. The Mouth Dissolving Films were formulated in five different batches F1 to F6 by using hydrophilic polymers HPMC E5, Salivary Stimulating Agent citric acid and PEG. All the formulations were prepared by Solvent casting method. The in vitro drug release profiles obtained for films made with combinations of HPMC E5 gives immediate release in 3-6 min. Preformulation studies were carried out by determining physical appearance, UV and FT-IR spectra of drug. Which identify the sample Solubility of Carbamazepine was determined in various aqueous and non aqueous solvent. Finally it can be concluded that selected drug and polymers fulfill the all parameters which can be required for the optimized Mouth Dissolving Films.
- Publication
International Journal of Pharmacy & Life Sciences, 2021, Vol 12, Issue 9, p1
- ISSN
0976-7126
- Publication type
Academic Journal