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- Title
FORMATION DEVELOPMENT AND EVALUATION OF MICROSPHERE OF QUERCETIN FOR THE TREATMENT OF COLON DISEASE OR INFLAMMATORY BOWEL DISEASES.
- Authors
Patel, M. K.; Shah, S. K.; Tyagi, C. K.; Md. Usman, Md. Rageeb
- Abstract
Microspheres constitute an important part of oral drug delivery system by virtue of their small size and efficient carrier capacity. However, the success of these microspheres is limited due to their short residence time at the site of absorption. The purpose of the present study was to prepare, characterize and evaluate the colon-targeted microspheres of quercetin for the treatment and management of inflammatory bowel diseases. Microspheres were prepared by the solvent evaporation method using ethyl cellulose and HPMC. Microspheres prepared were coated with eudragit S-100 using an oil-in-oil solvent evaporation method. Eudragit S-100 was used as enteric coating polymer with the aim to release the drug in small intestine. The effect of varying drug/polymer (D/P) ratios on microspheres characteristics were studied by 3² FFD. Desirability function was used to search the optimum formulation. The microspheres prepared were characterized by particle size, zeta potential, polydispersity index, shape and surface morphology, in vitro drug release and stability studies. The results of measurement of mean particle size of formulation F1, F2, and F3 microsphere were found 192±5, 196±4 and 195±6nm respectively. The drug entrapment of different formulations was found as 68.45±0.85, 73.32±0.45 and 65.58±0.35 percentage w/w. The microspheres formed have rough surface and spherical shape as observed in scanning electron microscopy. All values are statistically significant. It was observed that the coated microspheres showed no release in the simulated gastric fluid, negligible release in the simulated intestinal fluid and maximum release in presence of rat caecal content. It was concluded from the study that Eudragit-coated microspheres were promising carriers for colon-targeted delivery of quercetin.
- Publication
Journal of Advanced Scientific Research, 2020, Vol 11, p316
- ISSN
0976-9595
- Publication type
Academic Journal