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- Title
In-situ uniform generation of nano calcium-deficient hydroxyapatite/chitosan composite microspheres.
- Authors
GUO Yuanyuan; JI Jingou; TIAN Zhenzhen; ZHU Qin; WANG Dan; HAO Shiler
- Abstract
Aimed at the problem of nano calcium-deficient hydroxyapatite (nCT)HA) uneven distribution and insufficient content m nano calcium-deficient hydroxyapatite/chitosan (CS) composite microspheres. nCDHA/CS composite microspheres were firstly fabricated m situ by homogeneous precipitation method m a water-m-oil (W/O) emulsion. The physicochemical properties of composite microspheres were investigated by scanning electronic microscopy (SEM) . laser particle size analyzer. X-ray diffraction (XRT)) . Fourier infrared spectrum (FT-TR), thermogravimetric analysis (TG) and X-ray photoelectron spectroscopy (XPS). The results indicate that the nCDHA was uniformly distributed m the nCT)HA/CS composite microspheres. and the content was up to 4-3%. Moreover, the composite microspheres had a narrow size distribution, good sphericity with PDI 0.291 and average size of 18.6 /im. The result of biomimetic mineralization shows that the surface mineralization of composite microspheres was a process from nCDHA to nHA. After 14 d of biomimetic mineralization, a large number of even sheets of bone-like apatite were formed on the surface of the microspheres. indicating that the composite microspheres had good biological properties and great potential for bone tissue regeneration and repair.
- Publication
Journal of Functional Materials / Gongneng Cailiao, 2019, Vol 50, Issue 7, p07216
- ISSN
1001-9731
- Publication type
Academic Journal
- DOI
10.3969/j.issn.1001-9731.2019.07.039