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- Title
Chemical constituents and analgesic activity of Aconitum kusnezoffii Reichb.
- Authors
Qian Li; Shuding Sun; Meiying Wang; Caifeng Li; Dan Yuan; Hongzheng Fu
- Abstract
In the present study, we aimed to investigate the chemical constituents and analgesic activity of Aconitum kusnezoffii Reichb. The isolation and purification of components were achieved by a series of chromatography, including silica gel, Sephadex LH-20 and HPLC. By using spectroscopic analysis, their structures were identified. Using PDE-4A as analgesic target, molecular docking was conducted between isolated compounds by using Schrodinger software. Neoline is a typical non-ester diterpene alkaloid. It was studied by using the mouse torsion body method and hot plate method. A total of 12 diterpene alkaloids were obtained and identified as Mesaconitine (1), Bewutine (2), Bewudine (3), Songoramine (4), Songorine (5), Neoline (6), Talasamine (7), isotalatizidine (8), Hokbusine A (9), Mesaconine (10), 8-OEt-14-benzoylmesaconine (11), 8-Methoxy-14-benzoyl-beiwutinine (12). Compounds 9 and 12 were isolated from Aconitum kusnezoffii Reichb. for the first time. Twelve diterpene alkaloids could act on the analgesic target. Neoline is a typical non-ester diterpene alkaloid. It had significant analgesic effect. Diterpene alkaloids were the main components of Aconitum kusnezoffii Reichb., and they had good analgesic activity.
- Publication
Journal of Chinese Pharmaceutical Sciences, 2018, Vol 27, Issue 12, p855
- ISSN
1003-1057
- Publication type
Academic Journal
- DOI
10.5246/jcps.2018.12.087