We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
CNR2 基因多态性与汉族绝经女性骨质疏松症的遗传关联研究.
- Authors
李苗; 周琦; 张晨; 马骏; 班文瑞
- Abstract
Objective To investigate whether CNR2 gene, which has been shown to be related to osteoporosis in some populations,is associated with bone mineral density (BMD) or osteoporosis in Han Chinese postmenopausal women. Methods We examine 39 SNPs covering the region of CNR2 gene in 3121 Han Chinese postmenopausal women, consisting of 1032 osteoporosis patients and 2089 healthy controls, and evaluated their association with BMD and osteoporosis. Results We found that rs4237 and rs2501431 were significantly associated with BMD and osteoporosis (corrected P = 0. 020 and 0. 017) in our sample, and the TT genotype of rs2501431 and the AA genotype of rs4237 had lower lumbar spine and femoral neck BMD compared with other genotypes. Additionally, analyses by haplotypes indicated that two haplotype blocks, containing rs4237 and rs2501431 respectively, in the CNR2 gene significantly associated with BMD and osteoporosis (both global permutation P < 0. 001), and a risk haplotype (ATTT) in the block of rs3003336-rs2501431-rs2502992-rs2501432 had an almost 4-fold increase in the osteoporosis cases. Conclusion Our results provide further supportive evidence for an important role of CNR2 gene in the etiology of osteoporosis and suggest that it may be a genetic risk factor for BMD and osteoporosis in Han Chinese postmenopausal women.
- Publication
Chinese Journal of Osteoporosis, 2016, Vol 22, Issue 8, p951
- ISSN
1006-7108
- Publication type
Academic Journal
- DOI
10.3969/j.issn.1006-7108.2016.08.003