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- Title
Biomimetic synthesis of a novel antibacterial nano-composite materials of hydroxyapatite and gelatin for bone repair and its biocompatibility in vitro.
- Authors
DOU Xiao-chen; LI Quan-li; ZHOU Jian; TANG Jian
- Abstract
PURPOSE: To evaluate the bioactivity of a new type of antibacterial nano-composite materials of low-crystallinity hydroxyapatite and gelatin for bone repair in vitro. METHODS: The nanocomposite was prepared by a biomimetic method. A certain amount of acidic solution containing hydroxyapatite and minocycline was added into gelatin solution at 40°C and pH 7-8 to obtain HA-Gel composite containing anti-bacterial drug minocycline. The material was co-cultured with rat bone marrow stromal cells (BMSCs) in vitro. RESULTS: The results indicated that the nanoscopic low-crystallinity hydroxyapatite was distributed evenly in the fibrils of the composite by controlling crystal growth. The HA-Gel nanocomposite had complicated porous structure. It could promote BMSCs adhesion, proliferation, and differentiation in vitro. CONCLUSIONS: The BMSCs response to the material considerably shows that it is bioactive. The nanocomposite may be promising as a kind of materials for bone replacement and a carrier for controlled-release therapeutic agents. Supported by National Natural Science Foundation of China(Grant No.30772440) and Key Science and Technology Research Project of Anhui Province(Grant No.08010302196).
- Publication
Shanghai Journal of Stomatology, 2010, Vol 19, Issue 3, p285
- ISSN
1006-7248
- Publication type
Academic Journal