We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Development of cytochrome P450 in mediating metabolic resistance and applications for mosquito control.
- Authors
PENG Hui; LIU Hong-mei
- Abstract
With the long-term and large-scale application of chemical insecticides in public health and agricultural sectors, the occurrence and development of mosquito resistance has led to unprecedented challenges for the control of vector diseases. At present, studies have shown that metabolic resistance is one of the main resistance mechanisms of mosquito resistance. Cytochrome P450, as an important family of enzymes related to metabolic resistance, participates in the biotransformation and metabolism of endogenous and exogenous compounds in mosquitoes. CYP6, CYP9 and CYP4 families are the main enzymes of cytochrome P450 mediated mosquito metabolic resistance. In recent years, with the development of bioinformatics and molecular biology technology, more comprehensive and in-depth studies have been made on mosquito genome-wide resistance genes and resistance mechanisms. More and more CYPs have been found and confirmed to be related to mosquito drug resistance and applied to related vector control and resistance management. This paper briefly introduces the basic research of CYPs in mosquito metabolic resistance, as well as the related research progress in mosquito control and mosquito resistance management.
- Publication
China Tropical Medicine, 2022, Vol 22, Issue 1, p79
- ISSN
1009-9727
- Publication type
Academic Journal
- DOI
10.13604/j.cnki.46-1064/r.2022.01.17