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- Title
Antimicrobial, antiquorum sensing and antiproliferative activities of sesquiterpenes from Costus speciosus rhizomes.
- Authors
Ibrahim, Sabrin Ragab Mohamed; Al-Din Ahmed El-Shaer, Nagwa Salah; Asfou, Hani Zakaria; Elshali, Khalid Zaki; Shaaban, Mona Ibrahim Awad; Al-Attas, Ahmed Alawi Mohsen; Mohamed, Gamal Abd Allah
- Abstract
The quorum sensing inhibitory (QSI) and antimicrobial potentials of the total methanol extract (TME) and different extractives as well as the sesquiterpenes: dehydrodihydrocostus lactone (1), dehydrocostus lactone (2), arbusculin A (3), santamarine (4), reynosin (5), and specioic acid (6) isolated from Costus speciosus rhizomes were evaluated. The CHCl3:EtOAc (1:1), EtOAc, and TME fractions exhibited potent antibacterial activity toward B. cereus with inhibition zone diameter 13 mm. While the CHCl3 fraction showed strong activity towards S. aureus and B. cereus with inhibition zone diameter 11 and 19 mm, respectively. Moreover, the TME and CHCl3 fractions have strong activity towards C. albicans with inhibition zone diameter 15 and 12 mm, respectively. Compound 5 showed prominent activity towards B. cereus (MIC 385 µg/mL). However, 6 exhibited significant activity with MIC values of 150, 400, and 550 µg/mL towards S. aureus, E. coli, and B. cereus, respectively. Moreover, it showed potent antifungal effect towards C. albicans (MIC 320 µg/mL). Most of the tested fractions had QSI activity against C. violaceum. Only compound 6 exhibited moderate QSI effect with disappearance of violet pigment. In addition, compounds 1-6 were evaluated for their in vitro antiproliferative activity towards KB, BT-549, SK-MEL, and SKOV-3 cancer cell lines.
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2019, Vol 32, Issue 1, p109
- ISSN
1011-601X
- Publication type
Academic Journal