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- Title
Structural brain changes in the emotional network in adult patients with ADHD compared to patients with major depression and healthy volunteers.
- Authors
Frodl, Thomas; Amico, Francesco; Stauber, Julia; Schaaff, Nadine; Koutsouleris, Nikolaos; Reiser, Maximilian; Möller, Hans-Jürgen
- Abstract
Introduction and objectives: The neurobiological underpinnings of comorbidity in adult ADHD are unclear. To investigate whether adult ADHD patients may exhibit gray and/or white matter volumetric abnormalities compared to healthy volunteers and patients with major depression. Methods: Twenty adult patients with ADHD, 20 patients with major depression and 20 healthy controls (matched for age and gender) were investigated using high-resolution magnetic resonance imaging. Results: Smaller volumes were detected in the right and left anterior cingulate cortex and in the amygdala in patients with ADHD compared to patients with major depression and healthy controls. Hyperactivity, Inattention and symptoms of depression were associated amygdala volumes. Discussion: Adults with ADHD exhibit smaller ACC and amygdala volumes. The present study supports findings that the emotional neural network, which includes amygdala and the ACC, plays an important role in the systemic brain pathophysiology of adult ADHD. Conclusion: Whether symptoms of patients with ADHD, who show structural brain changes in the emotional network, are more likely to persist into adulthood compared to those with no or less structural brain changes needs further investigation.
- Publication
European Child & Adolescent Psychiatry, 2010, Vol 19, pS79
- ISSN
1018-8827
- Publication type
Academic Journal
- DOI
10.1007/s00787-010-0117-5