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- Title
حساسیت، ویژگی و ارزش اخباری مثبت در کیت های غربالگری ویروسی اهداکنندگان سازمان انتقال خون ایران در دو گروه پرخطر و کم خطر در سال های 7931 تا نیمه اول سال 7931.
- Authors
سارا ریاحي; صدیقه امیني کافي; داریوش مینایي طه; مهتاب مقصودلو; سید مؤید علویان
- Abstract
Background and Objectives Assessing the sensitivity, specificity and positive predictive value (PPV) of blood-borne infections detection kits are important indicators in the evaluation and use of the kit. Materials and Methods The present study is a descriptive study. The sensitivity of the kit was calculated using the panels of Boston Biomedica Company, definite positive samples of Iranian patients, and the specificity and PPV of the kits in two groups of low-risk 1646371) and high-risk (2525). The results were analyzed with descriptive statistics, SPSS 26, and OR statistical test. (p < 0.05) Results In evaluating Monalisa HBs Ag ULTRA, Bio-Rad, and Genscreen ULTRA HIV Ag/Ab kits, Bio-Rad is even more sensitive than reference kits (Enzygnost HBsAg 6 0, Siemens, HIV Ag/Ab Biomerieux) and in the case of Monalisa Anti-HCV kit PLUS Version 3, Bio-Rad sensitivity was equal to 98 6% of the reference kit (Ortho HCV 3 0 Enhanced SAVE). The results of the specificity evaluation in the high-risk group by three kits of HBs Ag, Anti HCV, and HIV Ag/Ab were 99 56%, 100%, and 99 80%, respectively. The results of the evaluation of PPV in the same three kits in the low-risk group were 41 4%, 31 30%, and 6 07% and in the high-risk group they were reported to be 72 5%, 100% and 37 5%, respectively. Conclusions The results of the present study, in addition to the appropriateness of sensitivity and specificity of the studied kits, showed a significant difference in PPV in communities with different viral prevalence and emphasized the importance of paying attention to prevalence in order to select kits and methods used for viral screening or diagnosis.
- Publication
Scientific Journal of Iranian Blood Transfusion Organization, 2021, Vol 18, Issue 3, p1
- ISSN
1027-9520
- Publication type
Academic Journal