We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Sensory Neuron Mechanisms Underlying Thiamine-Induced Inhibition of Hyperalgesia in Rats With Chronic Compression of Dorsal Root Ganglion.
- Authors
Huang, Z. J.; Song, X. S.; Song, X. J.
- Abstract
Background and Objective: Neuropathic pain is severe and often intractable and continues to pose major clinical challenges. Our recent studies show that B vitamins thiamine, pyridoxine, and cyanocobalamin and their combinations may relieve pain and hyperalgesia in rats with sciatic nerve injury or dorsal root ganglion (DRG) compression, suggesting the possible clinical utility of B vitamins in treatment of nueuropathic painful conditions following injury, inflammation, degeneration, or other disorders of the nervous systems in patients. Neural mechanisms underlying such analgesia remain unknown. Injury or inflammation affecting the axons or somata of sensory neurons having their somata in DRG often causes hyperexcitability that may lead to spontaneous firing and neuropathic pain. We further investigated possible roles of the B vitamins in hyperexcitability of the sensory neurons in rats with DRG compression. Methods: Intracellular and whole cell patch-clamp recordings were made in vitro from intact and/or dissociated DRG neurons. Results: Administration of thiamine in vitro (1-10 mM, DRG perfusion) or in vivo (i.p., 33-100 mg/kg/day, 7-10 days until the day of electrophysiological recording) significantly reversed the decreased threshold current and increased the discharge rate of action potential of the DRG somata. DRG compression-induced reduction of slow sodium currents in the nociceptive neurons was significantly reversed by thiamine treatment in vivo or in vitro. Conclusion: These results suggest that thiamine may reduce pain and hyperalgesia by depressing the neural hyperexcitability via modulating the abnormal expressed sodium currents. This study was supported by PCCBRF-VB002.
- Publication
Journal of Chiropractic Education (Association of Chiropractic Colleges), 2008, Vol 22, Issue 1, p63
- ISSN
1042-5055
- Publication type
Academic Journal