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- Title
S17.2: IL‐27 contributes to antiviral immune responses during congenital infection.
- Abstract
In contrast, we found that the placental tissues of IL-27-neutralized dams had significantly higher ZIKV titers relative to the placental tissues of infected control dams, suggesting a potential antiviral role for IL-27 in the placenta. We blocked IL-27 signaling through administration of IL-27 neutralization antibody prior to and throughout congenital Zika virus infection. B Method of Study b : Using an immunocompetent model of Zika virus infection, we evaluated infection outcomes in the presence or absence of immunoregulatory cytokine IL-27.
- Publication
American Journal of Reproductive Immunology, 2022, Vol 87, p69
- ISSN
1046-7408
- Publication type
Academic Journal
- DOI
10.1111/aji.84_13546