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- Title
Involvement of monoaminergic system in the antidepressant-like effect of aqueous extract of Channa striatus in mice.
- Authors
SALEEM, A. M.; HIDAYAT, M. TAUFIK; JAIS, A. M. M.; FAKURAZI, S.; MOKLAS, M. A. M.; SULAIMAN, M. R.; AMOM, Z.; BASIR, R.
- Abstract
BACKGROUND: In our previous study, the aqueous extract of Channa striatus (family: Channidae) fillet (AECSF) showed an antidepressant-like effect in mice. However, the mechanism of the antidepressant-like effect is unknown. AIM: The objective of this study was to explore the involvement of monoamines in the antidepressant-like effect of AECSF in mice. MATERIALS AND METHODS: AECSF was prepared by steaming the fillets of C. striatus. The male ICR mice were pretreated with various monoaminergic antagonists viz., p-chlorophenylalanine (100 mg/kg, i.p.), prazosin (1 mg/kg, i.p.) and yohimbine (1 mg/kg, i.p.), SCH23390 (0.05 mg/kg, s.c.) and sulpiride (50 mg/kg, i.p.) followed by treatment with AECSF and tested in tail suspension test (TST). Two-way ANOVA with Tukey test were used at p < 0.05 for significance. RESUL TS: The pretreatments with p-chlorophenylalanine, prazosin and yohimbine, but not with SCH23390 and sulpiride, were able to reverse the antidepressant-like effect of AECSF inTST. CONCLUSIONS: The antidepressant-like effect of AECSF may be mediated through the serotonergic and noradrenergic systems and not through the dopaminergic system.
- Publication
European Review for Medical & Pharmacological Sciences, 2013, Vol 17, Issue 15, p2019
- ISSN
1128-3602
- Publication type
Academic Journal