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- Title
Foetal maternal haemorrhage detection with the Kleihauer technique for postnatal immunoglobulin dose evaluation in Sudan.
- Authors
Ali MSM; El Amin AYM; Gamal M; Abdulla N; Mohamed A
- Abstract
Objective: The intent of this study was to evaluate the standard routine dose (500 IU) of Rh immune globulin (RHIG) therapy, which is offered routinely to all RhD-negative mothers delivering RhD-positive babies in Sudan.Methods: Blood samples from 140 pregnant women who were admitted for delivery to various Khartoum State hospitals were tested by the Kleihauer technique to determine the amount of fetomaternal haemorrhage (FMH) in the maternal circulation.Results: The results of the study demonstrated that the circulation of 10 out of 140 mothers (7.1%), tested by the Kleihauer method, contained more than 4ml of foetal blood. In addition, the association between foetal haemorrhage and mothers' age, duration of pregnancy, baby weight, circumcision of the mother (cutting of the clitoris), type of delivery, and mothers' gravida was statistically insignificant.Conclusions: The study concluded that 7.1% of mothers had a possibility of greater than 4ml of FMH. For these mothers, the standard RHIG dose of 5001U would be inadequate and they would need additional RHIG to prevent sensitization and potential harm to future babies. It is recommended to test all RhD-negative women delivering RhD-positive babies routinely with the Kleihauer method for detection and quantitation of FMH in order to determine the correct dose of RHIG to be administered.
- Publication
New Zealand Journal of Medical Laboratory Science, 2005, Vol 59, Issue 1, p6
- ISSN
1171-0195
- Publication type
Academic Journal