We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Amiodarone and risk of liver cirrhosis: a nationwide, population-based study.
- Authors
Huang, Ching-Hui; Lai, Ya-Yun; Kuo, Yu-Jui; Yang, Su-Ching; Chang, Yu-Jun; Chang, Kuo-Kuan; Chen, Wen-Kang
- Abstract
<bold>Background: </bold>Liver cirrhosis is an uncommon but not rare side effect of amiodarone-induced hepatotoxicity. Patients with hepatitis B virus and hepatitis C virus infections are at a high risk for developing liver cirrhosis. However, the relationship between this treatment and risk of liver cirrhosis in high-risk chronic hepatitis B and chronic hepatitis C patients is unknown.<bold>Patients and Methods: </bold>The present study identified amiodarone users (N=8,081) from the Taiwan National Health Insurance Research Database from 1997 through 2013. A total of 32,324 subjects with age, comorbidities, gender, and index date-matched non-amiodarone users were selected as controls (non-amiodarone cohort). The incidences of cumulative liver cirrhosis were compared between cohorts. Stratified Cox's regression hazard models were used to assess possible comorbidity-attributable risks for liver cirrhosis.<bold>Results: </bold>The amiodarone cohort had a nonsignificant risk of liver cirrhosis compared with the non-amiodarone cohort, with a HR of 1.17 (95% CI: 0.93-1.47; P=0.1723). Patients with specific comorbid diseases, including type 2 diabetes mellitus, chronic hepatitis B, chronic hepatitis C, and heart failure, were probably at a high risk of developing liver cirrhosis. The use of statins was associated with a significant 42% reduction in the risk of liver cirrhosis.<bold>Conclusion: </bold>Patients in the amiodarone cohort had no excess risk of liver cirrhosis compared with patients in the non-amiodarone cohort. Long-term surveillance for liver toxicity in high-risk patients with amiodarone treatment is suggested.
- Publication
Therapeutics & Clinical Risk Management, 2019, Vol 15, p103
- ISSN
1176-6336
- Publication type
Academic Journal
- DOI
10.2147/TCRM.S174868