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- Title
Successful Treatment of Meningoencephalitis due to Cryptococcus gattii with Ommaya Reservoir and Intrathecal Injection of Amphotericin B - a Case Report.
- Authors
Ch. Chang-Hua; W. Shao-Hung; Y. Hua-Cheng; W. Wang-Fu; Ch. Wei Liang; Y. Yung-Jen; Ch. Yu-Min; H. Chieh-Chen
- Abstract
Cryptococcal meningitis (CM) is a potential ly fatal disease. We report successful treatment with the Ommaya reservoir and intrathecal injection of amphotericin B for the control of refractory cerebral cryptococcosis due to Cryptococcus gattii AFLP4/VGI. A 63-year-old male patient presented with a 2-week history of fever and headache, and was he dia gnosed with CM. Combined amphotericin B and 5-flucytosine treatment was initiated and fol lowed by fluconazole therapy. After 7 months, he was refractory to traditional CM treatment and received salvage therapy with an Ommaya reservoir and intrathecal injection of amphotericin B. His neurological symptoms recovered gradually with no evidence of relapse during 12-month fol low-up. The isolate was re-identified by culturing in canavanine-glycine-bromothymol Blue media and by molecular typing us ing URA5 as Cryptococcus gattii AFLP4/VGI. The Ommaya reservoir could serve as an alternative treatment for Cryptococcus gattii AFLP4/VGI-induced CM, which responds poorly to standard regimens.
- Publication
Česká a Slovenská Neurologie a Neurochirurgie, 2017, Vol 80, Issue 3, p337
- ISSN
1210-7859
- Publication type
Academic Journal
- DOI
10.14735/amcsnn2017337