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- Title
The effect of gold and silver nanoparticles on HaCaT cell lines.
- Authors
Pivodova, Veronika; Ulrichova, Jitka
- Abstract
Skin wound healing is a highly regulated process, involving re-epithelization, matrix deposition and remodeling. The skin is an epithelium consisting of several cell types such as Langerhans cells, melanocytes and keratinocytes. Keratinocytes are the most abundant cell types, which synthesize major structural components of the epidermal barrier. The repair process is initiated immediately after injury by the release of various cytokines, matrix metalloproteinases and low-molecular weight compounds in the extracellular matrix. Antibacterial properties of silver and anti-inflammatory properties of gold nanoparticles are described in literature. In our work, we have studied two samples of silver (ionic silver and metallic silver) and one sample of gold (nanogold) on the biomarkers involved in the wound healing process such as collagen type I, interleukin- 6 (IL-6), matrix metalloproteinase-1(MMP-1), -3 (MMP-3) and -10 (MMP-10) on HaCaT cell lines. Our results have demonstrated that all the samples of metals decreased the production of IL-6. In addition, it was shown that ionic silver might have a positive effect on wound healing because of increased production of proteins that promote keratinocyte migration (collagen type I, MMP-1) and contraction of the wound (MMP-3). We are planning to study other effects of silver and gold on skin wound healing.
- Publication
Biomedical Papers of the Medical Faculty of Palacky University in Olomouc, 2012, Vol 156, Issue Supp 3, pS123
- ISSN
1213-8118
- Publication type
Academic Journal