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- Title
Relationship of NLRP3 inflammasome in blood, IL-1 beta and il-18 cytokine level with cognition in OCD.
- Authors
Önder, Betül; Oktay, Melike Tetik; Direk, Neşe; Aykaç, Cansu; Ekinci, Burcu; Yaraş, Tutku; Kuruoğlu, Aykut; Ermiş, Çağatay; Oktay, Yavuz; Alkın, Tunç
- Abstract
Objective: Research showed that inflammatory processes are included in many psychiatric disorders. NLRP3 Inflammasome which is formed by combination of NLRP3, ASC and Caspase-1 proteins and its activator NEK7 has a role in these processes. Relationship between neuropsychiatrîc diseases and NLRP3 has been previously detected, and its relationship with OCD has been shown for the first time by our research group. Findings of possible relationships between IL-1(3 and IL-18, which are the result of activation of NLRP3 inflammasome and neurocognitive impairment in OCD are limited. Cytokines may regulate cognition and neuronal-glial cell function for neurodegeneration or neuroregeneration. We aimed to investigate relationship between IL-1(3, IL-18 cytokine levels, NLRP3, ASC, Caspasel, NEK7 gene expression-protein levels, and cognition in OCD. Methods: The study was performed at Dokuz Eylül University Hospital. 42 OCD patients aged between 18-45 were included. SCID-1, Y-BOCS, Hamilton Depression Scale were applied. Trail Making Test (TMT), Berg Card Sorting Test and Category Fluency Test were administered to evaluate cognitive functions. Schizophrenia, bipolar disorder etc. and inflammatory conditions were exluded. Cytokine levels were assessed by ELISA; NLRP3, Caspase-1, ASC, and NEK7 gene expressions were determined qPCR. Evaluation of the amount of protein encoded by the same genes was performed by Western Blotting. Results: Weak negative correlations were found between IL-1(3 and TMT (B-A) (rs=-.36, p=0.019); NEK7 protein level and TMT-B (rs=-.3, p=O.O33). A weak negative correlation between TMT-B, TMT (B-A) and ASC protein levels was significant (rs=-.38, p=0.03; rs=-0.36, p=0.04, respectively). There was no relationship between other biological and cognitive variables (p>0.05). Conclusion: IL-1(3, NEK7, and ASC levels may be associated with impaired cognition in OCD. Studies with larger samples about inflammatory processes are needed to develop new diagnosis/treatment methods.
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2020, Vol 14, pS126
- ISSN
1307-8798
- Publication type
Academic Journal