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- Title
EFFECT OF QUERCETIN ON STRESS INDUCED CHANGES IN INTERLEUKIN 6 (IL-6) LEVELS IN ALBINO RATS.
- Authors
H. S., Nagaraja; Radhakrishnan, Ammu; Kumar, Ponnusamy
- Abstract
Introduction: Stressors can directly affect the cells of the immune system and modulate the secretion of proinflammatory cytokines. Stress related immune dysregulation may be one of the central mechanisms behind a large and diverse set of health risks associated with chronic stress. Bioflavonoid quercetin is a powerful antioxidant and also known to have immunomodulatory effect. Our objective was to determine if pretreatment with quercetin affects the stress induced modulation in proinflammatory cytokine levels in albino rats. Methodology: Male albino rats were (i) treated with saline (ii) treated with quercetin alone (15mg/ kg body weight; intraperitoneally) (iii) exposed to swimming stress ( for 5 days; acute stress group(iv) pretreated with quercetin, 30 minutes before acute stress (v) exposed to swimming stress ( for 15 days; chronic stress) (vi) pretreated with quercetin 30 minutes before chronic stress. At the end of the experiment, animals were sacrificed and serum interleukin -6 levels were estimated. Results: There was a significant increase in the interleukin 6 levels in both acute and chronic stressed animals when compared to control and quercetin alone group. Pretreatment with quercetin reduced the proinflammatory cytokine levels significantly irrespective of the duration of stress. Quercetin alone also had significantly reduced the IL-6 levels in the rats. Conclusion: Forced swimming increases the proinflammatory cytokine, IL-6 levels after acute and chronic stress exposure. Pretreatment with bioflavonoid quercetin reduced the stress induced increase in interleukin 6 levels. Quercetin inhibition of inflammatory responses may protect the organism against pathophysiology of chronic stress.
- Publication
Malaysian Journal of Medical Sciences, 2007, Vol 14, p170
- ISSN
1394-195X
- Publication type
Academic Journal