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- Title
Ligand-Directed Selective Protein Modification Based on Local Single-Electron-Transfer Catalysis.
- Authors
Sato, Shinichi; Nakamura, Hiroyuki
- Abstract
A photocatalyst ([Ru(bpy)3]2+) bound to a protein ligand was essential for the title method. Local single‐electron transfer from the catalyst resulted in the formation of tyrosyl radicals. N′‐Acetyl‐N,N‐dimethyl‐1,4‐phenylenediamine was used as the tyrosyl radical trapping agent and used in a radical addition to afford selective modification of the target protein.
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 33, p8681
- ISSN
1433-7851
- Publication type
Academic Journal
- DOI
10.1002/anie.201303831