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- Title
Best Oral Presentations (OP01–OP12).
- Authors
Geçene, Muharrem; Tuncay, Figen; Borman, Pınar; Yücel, Doğan; Şenes, Mehmet; KaniyeYılmaz, Bedriye
- Abstract
Background: The aim of this study was to determine the intima-media thickness (IMT) as an indicator of subclinical atherosclerosis in carotid arteries and to assess the relation of these values with homocystein levels and Methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in patients with AS.Methods: Fifty male AS patients and 50 controls were included in the study. Serum lipids, vitamin B12, folic acid, homocystein and acute phase protein levels were measured in all cases. A plasma homocystein level of > 17 µmol/L was considered as hyperhomocysteinemia. MTHFR C677T gene polymorphisms were determined and IMT of main carotid artery were evaluated ultrasonographically in all subjects. BASDAI, ASDAS and BASMI were used to assess disease activity and spinal mobility. The relationship between plasma homocystein level, MTHFR C677T gene polymorphism, IMT values and clinical characteristics were determined.Results: Fifty AS patients (mean age of 36.6 ± 4.79 years) and 50 control subjects (36.34 ± 4.72 years) were included to the study. Demographic characteristic were smiliar between the groups. Plasma homocystein levels of AS patients and control group were also smiliar (14.26 ± 9.96 vs 11.81 ± 5.53 µmol/L). Hyperhomocysteinemia was present in 11 subjects in patient group (%22.0), while it was seen in 5 subjects in the control group (%10.0), and MTHFR C677T genotype distribution was CC 31 (%62), CT 14 (%28), TT 5 (%10) in AS patients and CC 26 (%52), CT 22 (%44), TT 2 (%4) in the control group, with no significant difference between groups (p = 0.102, p = 0.174) and the mean carotid IMT values were found to be similar between the groups. No relation was found between plasma homocystein levels and clinical and demographical properties. The most important factor influencing homocystein level was found as MTHFR 677TT genotype, which was established to increase the risk of hyperhomocyteinemia risk by 11.308 fold.Conclusions: In the present study, carotid IMT values, indicating subclinical atherosclerosis, were found to be similar in AS and control groups. The increase in the risk of atherosclerosis in AS patients seems not be different from healthy subjects.Disclosure statement: None.
- Publication
Rheumatology, 2012, Vol 51, Issue suppl_1, pi15
- ISSN
1462-0324
- Publication type
Academic Journal
- DOI
10.1093/rheumatology/ker437