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- Title
Indications, results and safety profile of transperineal sector biopsies ( TPSB) of the prostate: a single centre experience of 634 cases.
- Authors
Vyas, Lona; Acher, Peter; Kinsella, Janette; Challacombe, Ben; Chang, Richard T.M.; Sturch, Paul; Cahill, Declan; Chandra, Ashish; Popert, Richard
- Abstract
Objective To describe a protocol for transperineal sector biopsies ( TPSB) of the prostate and present the clinical experience of this technique in a UK population., Patients and Methods A retrospective review of a single-centre experience of TPSB approach was undertaken that preferentially, but not exclusively, targeted the peripheral zone of the prostate with 24-38 cores using a 'sector plan'. Procedures were carried out under general anaesthetic in most patients., Between January 2007 and August 2011, 634 consecutive patients underwent TPSB for the following indications: prior negative transrectal biopsy ( TRB; 174 men); primary biopsy in men at risk of sepsis (153); further evaluation after low-risk disease diagnosed based on a 12-core TRB (307)., Results Prostate cancer was found in 36% of men after a negative TRB; 17% of these had disease solely in anterior sectors., As a primary diagnostic strategy, prostate cancer was diagnosed in 54% of men (median PSA level was 7.4 ng/mL)., Of men with Gleason 3+3 disease on TRB, 29% were upgraded and went on to have radical treatment., Postoperative urinary retention occurred in 11 (1.7%) men, two secondary to clots. Per-urethral bleeding requiring hospital stay occurred in two men. There were no cases of urosepsis., Conclusions TPSB of the prostate has a role in defining disease previously missed or under-diagnosed by TRB. The procedure has low morbidity.
- Publication
BJU International, 2014, Vol 114, Issue 1, p32
- ISSN
1464-4096
- Publication type
Academic Journal
- DOI
10.1111/bju.12282