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- Title
Treatment of lower urinary tract symptoms suggestive of benign prostatic hyperplasia: the cardiovascular system.
- Authors
Barendrecht, Maurits M.; Koopmans, Richard P.; de la Rosette, Jean J. M. C. H.; Michel, Martin C.
- Abstract
This article focuses on the treatment of lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia. In recent years medical treatment has become the mainstay of care for most patients with LUTS/BPH. The general circulation comprises a low pressure (venous) and a high-pressure (arterial) system, with most of the circulating blood volume residing in the low-pressure system. When supine the distribution of the circulating blood between the arterial and the venous system is determined by the pumping of the heart and the relative resistances of arteries and veins. Nevertheless, most people do not experience such problems when standing, because the sympathetic nervous system provides a fast and powerful counter-regulatory mechanism to increase venous tone and thereby the return of blood to the heart, making it available for tissue perfusion. The sympathetic nervous system accomplishes this mainly by releasing noradrenaline, which contracts arterial and venous blood vessels mainly via alpha adrenoceptors.
- Publication
BJU International, 2005, Vol 95, p19
- ISSN
1464-4096
- Publication type
Academic Journal
- DOI
10.1111/j.1464-410X.2005.05487.x