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- Title
BIOACTIVITY-GUIDED ISOLATION OF α-GLUCOSIDASE INHIBITORY AND TYROSINASE ACTIVE CONSTITUENTS IN ANGELICA DAHURICA ROOTS.
- Authors
Juanjuan Zhang; Zhenhua Yin; Miyun Hu; Jinmei Wang; Wenyi Kang
- Abstract
The aim of this study was to isolate α-glucosidase inhibitory and tyrosinase constituents from 70% ethanol extracts of Angelica dahurica roots by bio-assay guided method. Six compounds were isolated and identified in active fractions Fr.5, Fr.6 and Fr.7. Compound 4 and 5 were isolated from A. dahurica for the first time. Their chemical structures were determined by spectroscopic methods, including NMR, MS, GC-MS analyses. Compound 3 and 4 showed stronger inhibitory activity on α-glucosidase activity with inhibition rates of 98.41% and 99.05%. Compound 1, 3 and 4 displayed inhibitory effects on tyrosinase activity, while compound 5 had activating effect.
- Publication
Current Topics in Nutraceutical Research, 2018, Vol 16, Issue 2, p165
- ISSN
1540-7535
- Publication type
Academic Journal