We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Delay in local therapy adversely effects outcome of Wilms’ tumor: 19 years experience at the Princess Noorah Oncology Center, National Guard Hospital, Jeddah, KSA.
- Authors
Khattab, Taha M.; Kuzeljevic, Boris; Atra, Ayad; Baothman, Abdullah; Felimban, Sami; Binyahib, Suliman; Fayea, Najwa; Zayed, Abdullah; Immam, Najla; Gomah, Mohammed; Fryer, Chris
- Abstract
Preoperative chemotherapy and delayed nephrectomy, adopted by the SIOP has a similar outcome to immediate nephrectomy, advocated by the NWTSG. We compared the outcome and local relapse rate in patients with Wilms’ tumor who had immediate versus delayed nephrectomy. The files of all 58 patients diagnosed with Wilms’ tumor and treated at the National Guard Hospital, Jeddah between January 1986 and December 2004 were reviewed. Initial treatment was either primary nephrectomy, or in patients with bilateral or metastatic disease or where complete resection was deemed unlikely, true-cut biopsy and preoperative chemotherapy. Six bilateral cases remain relapse free. Three of six patients with unfavourable histology recurred locally and died. In the 46 favourable histology patients the overall five year survival was 76.6% +/- 6.5%.There were two (6.4%) local recurrences in the 31 patients with immediate nephrectomy vs. seven (44%) in the 15 that had delayed nephrectomy (p=0.003). The five year survival was 86.7% +/- 6.2% in the immediate nephrectomy group compared to 52.2% +/- 14.3% for the delayed nephrectomy group (p=0.023) There was a non significant trend towards a higher recurrence rate (6/10) if nephrectomy was delayed for > 56 days compared to (1/5) with nephrectomy within 56 days. In this study delayed nephrectomy was associated with a high local recurrence rate and poor survival.
- Publication
Cancer Therapy, 2009, Vol 7, p296
- ISSN
1543-9135
- Publication type
Academic Journal