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- Title
EFFECT OF CHLORELLA VULGARIS VS. SPIRULINA SUPPLEMENTATION ON LIPID PROFILE AND LIVER FUNCTION IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE: A RANDOMIZED CONTROLLED TRIAL.
- Authors
Chitsaz, Maryam; Mozaffari-Khosravi, Hassan; Salman-Roghani, Hassan; Zavar-Reza, Javad; Lotfi, Mohammadhassan
- Abstract
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease. Microalgae could be consumed as a functional food, as a new approach to improve metabolic disorders and fat accumulation in NAFLD patients. The present study aimed to compare Chlorella Vulgaris and Spirulina supplementation effect on lipid profile and liver function among NAFLD patients. This randomized controlled clinical trial was conducted on 66 patients with NAFLD whose disease was confirmed by ultrasonography. The patients were randomly allocated into three 22-member groups, who received daily 1g of Chlorella vulgaris (CG) or Spirulina tablets (SG) and the non-interventional group (NG) did not receive any medication for eight weeks. Anthropometric measurements and biochemical parameters have been measured including total cholesterol (TC), low-density lipoprotein cholesterol (LDLc), high-density lipoprotein cholesterol (HDL-c), Triglyceride (TG), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), and Alkaline phosphatase (ALP) at baseline and after 8 weeks. Comparison within groups demonstrated that only weight significantly decreased in the intervention groups. BMI and waist circumference of changes were assessed similar to weight. Lipid profiles mean of change did not have any significant difference between the intervention groups and NG. No significant changes in TC, LDL-c, and HDL-c were observed among the three groups. Mean of changes of ALT was significant between the NG and both intervention groups. It was decreased to 7.17±16.9 mg/dl in the intervention groups, and increased to 2.73±5.41 mg/dl in the NG. The results of this research indicated that Chlorella vulgaris supplementation could decrease weight and improve lipid profile and liver function in patients with NAFLD more than Spirulina supplementation.
- Publication
International Journal of Probiotics & Prebiotics, 2016, Vol 11, Issue 3/4, p127
- ISSN
1555-1431
- Publication type
Academic Journal