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- Title
The relationship of adiponectin with insulin resistance in nonalcoholic fatty liver disease.
- Authors
Rahmani, Mojtaba; Nezhadali, Masoume; Javad, Rastgar Moghaddam
- Abstract
Introduction: Nonalcoholic fatty liver disease is a global health problem, rising up to 70% in patients with type 2 diabetes mellitus. The pathogenesis of NAFLD is multifaceted and complicated. Adipokines, hormones secreted by adipose tissue, seem to participate in the pathogenesis of NAFLD. Adiponectin is an adipokine that is abundantly expressed in adipose tissue In the liver, adiponectin, decreases hepatic glucose production and reduces free fatty acid turnover. Therefore Adiponectin plays a role in the development of Insulin sensitivity. Insulin resistance, through the inhibition of lipid oxidation and increased fatty acid and triglycerides synthesis, is believed to be a key factor in the development of fatty liver. The aim of this study was to determine circulating adiponectin levels in patients with NAFLD and to correlate plasma adiponectin with insulin resistance. Methods: plasma levels of adiponectin and insulin were measured by ELISA kit (Mercodia Company, Sweden) and fasting blood sugar were measured through glucose oxidase in a group of 80 NAFLD patients and 80 controls. Continuous variables with and without normal distribution were compared using Student's t-test or the Mann-Whitney U test, respectively. Spearman's rank correlation coefficient was used to assess possible associations. SPSS software version 20 was used (P values < 0.05). Results: Plasma adiponectin was significantly lower in NAFLD patients than control (4.4 [3.8-6.6) vs. 6.4 (5.3- 804), p-value < 0.001]. However, we did not find significant difference F.B.S between the two groups, whereas insulin was significantly increased in patients with NAFLD. Moreover, NAFLD patients were significantly more insulin resistant. An inverse correlation was observed between adiponectin and homeostatic model assessment (HOMA) of insulin resistance (p-value < 0.001, r = -0.293). Conclusion: These data support a role for low circulating adiponectin in the pathogenesis of NAFLD. Moreover, adiponectin was inversely correlated with HOMA-IR, thus supporting the role of adiponectin in the link between insulin resistance and NAFLD, that is inversely correlated with insulin resistance.
- Publication
Iranian Journal of Gastroenterology & Hepatology (GOVARESH), 2017, Vol 22, Issue 3, p17
- ISSN
1560-7186
- Publication type
Academic Journal