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- Title
抗 GAD65 和抗 GABA<sub>B</sub>R 双抗体阳性自身免疫性脑炎 1 例 报告及文献复习.
- Authors
苏杭; 李佳; 曾慧宾; 陈加俊
- Abstract
To analyze the clinical performance and diagnosis process of the autoimmune encephalitis (AE) patients with positive double antibodies in the cerebrospinal fluid(CSF), and to provide the references for the diagnosis and treatment of such patients. Methods:The clinical manifestations, magnetic resonance imaging (MRI) of the head, electroencephalogram (EEG), CSF characteristics, and prognosis of one patient with AE positive for anti-glutamic acid decarboxylase ( GAD ) 65 and anti- γ -aminobutyric acid B receptor (GABABR) double antibodies in the CSF were retrospectively analyzed, and the literatures were reviewed. Results:The patient was a 47-year-old male with subacute onset and progressively aggravated symptoms, mainly presenting with headaches and episodic convulsions, and blurred consciousness. The MRI results of the head suggested that the lesions were located on the right side of the cerebral falx in the frontal and parieto-occipital lobes;the CSF was positive for the anti-GAD65 and anti-GABABR double antibodies, and the EEG results showed the abnormal spike and slow waves, so the patient was diagnosed as AE. After anti-inflammatory and other symptomatic treatments, the patient was gradually improved and was discharged;the patient was given continuous oral corticosteroid treatment, but after 5 months, the patient was relapsed with acute onset, presenting with convulsion accompanied by drooling from the corner of the mouth. The head MRI results showed there was an abnormal high signal in the right temporal lobe. After corticosteroid treatment, the patient was improved. Conclusion:The AE patients with positive double antibodies in CSF are more likely to relapse. Steroid anti-inflammatory treatment is effective. When intracranial lesions are located in the frontal and parieto-occipital lobes, it should be considered the possibility of symptoms such as convulsions. It is necessary to complete the EEG and the other inspections as soon as possible.
- Publication
Journal of Jilin University (Medicine Edition), 2023, Vol 49, Issue 6, p1604
- ISSN
1671-587X
- Publication type
Academic Journal
- DOI
10.13481/j.1671‑587X.20230626