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- Title
Preliminary research on the role of autophagy in rat liver regeneration.
- Authors
YIN Li; XU Cunshuan
- Abstract
Autophagy affects the liver regeneration (LR). However, the detailed mechanism remains to be elucidated. In order to explore the change and mechanism of autophagy in rat LR, we detected the expression changes of proteins in the signal pathways which regulate autophagy and the proteins associated with autophagy process by isobaric tags for relative and absolute quantitation (iTRAQ) combined with mass spectrometry (MS). The results indicated that the PI3K/Akt, mTOR and AMPK signaling pathways were activated. The ubiquitin- proteasome-related proteins and the membrane proteins and hydrolases associated with lysosome changed significantly. Autophagy up-regulated at the priming and progression stage in LR by the analysis from IPA. We proposed the hypothesis that lysosomes and mitochondria might coexist and explore the possible mechanism about that kind of coexistence.
- Publication
Chinese Journal of Bioinformatics, 2017, Vol 15, Issue 3, p156
- ISSN
1672-5565
- Publication type
Academic Journal
- DOI
10.3969/j.issn.1672-5565.20161222001