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- Title
白血病融合基因EVI1 的多态性与白血病发生风险的相关性.
- Authors
石媛; 毕小朵; 杨光路; 李晓华; 付俊鲜; 李天霞; 张称心
- Abstract
Objective: To investigate the association between leukemia fusion gene eukaryotic fusion site 1 (EVI1) polymorphism and risk of leukemia. Methods: Ninety children children with spurs admitted to our hospital from February 2017 to February 2019 were selected as study groups, and eighty-three healthy people were selected as control group. The 2 mL of peripheral venous blood of the two group in the morning were collected, the polymorphism of EVI1 in the two groups were detected by PCR. The general data were investigated and were given correlation analysis. Results: The EVI1 rs17561 gene has three genotypes of CC, CA and AA, and the EVI1 rs17561 gene distribution of the two groups were consistent with the Hardy-Weinberg equilibrium law that so the subjects were representative. The difference of EVI1 rs17561 genotype distribution compared between the two groups were statistically significant (P<0.05), and the EVI1 rs17561 gene CC genotype in the study group was significantly higher than that in the control group (90.0% vs. 75.9 %, P<0.05), and the frequency of allele C in the study group was significantly higher than that in the control group (96.7% vs. 80.7 %, P<0.05). Among the ninety children with bone spurs, 6 patients were diagnosed with leukemia, and the detection rate was 6.7 %, all of which were CC genotypes. In the leukemia group. The CC genotype of EVI1 rs17561 gene in the study group was significantly correlated with platelet count, risk stratification, and diagnostic typing (P<0.05). Multivariate logistic regression analysis showed that platelet count, risk stratification and diagnostic typing were the main factors affected the EVI1 rs17561CC genotype (P<0.05). Conclusion: The fusion gene EVI1 polymorphism in children with leukemia is more common, and it is mostly represented by the rs17561CC allele. This allele may be significantly related to platelet count, risk stratification, and diagnosis typing in patients with leukemia. Stratification and diagnosis are the main factors affecting the genotype of EVI1 rs17561CC.
- Publication
Progress in Modern Biomedicine, 2020, Vol 20, Issue 8, p1515
- ISSN
1673-6273
- Publication type
Academic Journal
- DOI
10.13241/j.cnki.pmb.2020.08.025