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- Title
血清ghrelin、β-EP、BMEC在手足口病中的水平变化及诊断价值.
- Authors
徐丽娟; 郝改领; 郑少敏; 张楠; 李清华; 张中馥
- Abstract
Objective: To study Analysis of the Changes of serum levels of Growth hormone releasing peptide (Ghrelin), β-endorphin (β-EP), brain microvascular endothelial cells (BMEC) in hand-foot-mouth disease and their diagnostic value. Methods: 150 HFMD patients treated in our hospital from June 2017 to October 2019 were selected as the study group, and a total of 120 children with physical examination in the Department of Children's Health Care in our hospital were selected as the control group. The changes of serum levels of Ghrelin, β-EP and BMEC and their predictive value were analyzed. Results: The serum ghrelin level in the study group was significantly lower than that in the control group, and the levels of β-EP and BMEC were significantly higher than those in the control group, with significant differences (P<0.05). The serum ghrelin of stage II patients was significantly higher than that of stage III and IV patients, the serum β-EP and BMEC of stage III patients were significantly lower than that of stage III and IV patients, the serum ghrelin of stage III patients was significantly higher than that of stage IV patients, the serum β-EP and BMEC of stage III patients were significantly lower than that of stage IV patients, the difference was significant (P<0.05). ROC results showed that the AUC of serum ghrelin in predicting HFMD was 0.955, the sensitivity was 85.62%, the specificity was 87.45%, and the cutoff value was 12.91 ng/ mL. The AUC of serum β-EP for predicting HFMD was 0.801, the sensitivity was 82.25%, the specificity was 83.56%, and the cut-off value was 196.87 ng/L. The AUC of serum BMEC in predicting HFMD was 0.974, the sensitivity was 84.18%, the specificity was 85.97%, and the cutoff value was 56.28 /mL. The combined detection had higher sensitivity and specificity than the single detection (P<0.05). Conclusions: Serum Ghrelin, β-EP and BMEC are related to the condition of patients with hand, foot and mouth disease, which is helpful to guide clinical diagnosis and treatment.
- Publication
Progress in Modern Biomedicine, 2021, Vol 21, Issue 24, p4774
- ISSN
1673-6273
- Publication type
Academic Journal
- DOI
10.13241/j.cnki.pmb.2021.24.036