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- Title
血管紧张素 II 及其 1 型受体拮抗剂在卵巢癌中的作用机制.
- Authors
龚礼萍; 孙立涛; 田家玮
- Abstract
Ovarian cancer is one of the most common malignant tumors in the female reproductive system. Because of its insidious onset, most patients are already in advanced stage when they have symptoms, and are prone to metastasis and recurrence. The mortality rate of ovarian cancer ranks first among gynecological malignant tumors. Therefore, it is very important to further explore the mechanism of ovarian cancer and find potential therapeutic targets. Angiotensin Ⅱ (Ang Ⅱ) is the most bioactive factor in renin-angiotensin system (RAS), mainly involved in the regulation of metabolism of the body′s blood pressure and salt water. At present, some studies found that it combined with the angiotensin type 1 receptor (AT1R) to activated related pathways and that is closely related to the process of the occurrence and development of ovarian cancer and metastasis. And AT1R antagonists angiotensin receptor blocker (ARB) can selectively bind to AT1R blocking Ang Ⅱ - AT1R pathways, thereby blocking or inhibit Ang Ⅱ role in ovarian cancer. Further study on the mechanism of Ang Ⅱ and its type 1 receptor antagonist in ovarian cancer may provide evidence for new therapeutic targets for ovarian cancer.
- Publication
Journal of International Obstetrics & Gynecology, 2022, Vol 49, Issue 1, p24
- ISSN
1674-1870
- Publication type
Academic Journal
- DOI
10.12280/gjfckx.20210248