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- Title
Short-term lifestyle modification alters circulating biomarkers of endothelial health in sedentary, overweight adults.
- Authors
Turk, James R.; Sun, Grace Y.; Guilford, Brianne L.; Toedebusch, Brian W.; McClanahan, Matt W.; Thomas, Tom R.; Rector, R. Scott
- Abstract
Obesity and inactivity are associated with endothelial dysfunction that may contribute to the development of atherosclerosis. We examined the effects of a short-term lifestyle intervention on circulating biomarkers of endothelial health. Nineteen overweight or obese (mean body mass index (BMI): 28.9 ±0.7 kg/m2) men and women underwent 6 weeks of body mass reduction induced by moderate energy restriction (~750 kcal/d; 1 kcal = 4.184 kJ) and aerobic training (~400 kcal/d). Fasting serum samples were collected at baseline and after reduction in body mass (week 6) to assess concentrations of nitrotyrosine (NT), secretory phospholipase A2 (sPLA2), and soluble intracellular adhesion molecule-1 (sICAM-1). Body mass was significantly reduced from 81.3 ±2.8 to 77.3 ±2.6 kg (p < 0.05). Circulating concentrations of NT and sICAM-1 were significantly reduced with treatment (~25% and ~10%, respectively), whereas sPLA2 levels were significantly elevated (~45%). Elevations in sPLA2 were negatively correlated with changes in NT (r = –0.58, p = 0.047); reductions in NT did not correlate significantly with reductions in sICAM-1. It appears that circulating markers of endothelial health are susceptible to short-term exercise interventions with modest reduction in body mass, and such a lifestyle modification may improve endothelial health by reducing protein nitration products and cellular adhesion.
- Publication
Applied Physiology, Nutrition & Metabolism, 2006, Vol 31, Issue 5, p512
- ISSN
1715-5312
- Publication type
Academic Journal
- DOI
10.1139/H06-040