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- Title
Witamina D - rekomendacje czy też konieczność indywidualizacji dawek?
- Authors
Kołłątaj, Witold; Kołłątaj, Barbara; Klatka, Maria; Wrzołek, Katarzyna; Krzewska, Aleksandra
- Abstract
Due to the general lack of vitamin D, in the countries of Central Europe, there are published recommendations suggesting the need for supplementation of cholecalciferol. Objective. The aim of this study was to evaluate the effectiveness of prevention of vitamin D deficiency in children and adolescents suffering from hypovitaminosis D in the absence of medical history suggesting the risk of hypovitaminosis and indications for determining the levels of 25OHD (guidelines on cholecalciferol supplementation published in 2013). Material. The study included 105 children and adolescents - patients of the Department of Paediatric Endocrinology and Diabetology as well as Endocrinology Clinic of the University Children's Hospital in Lublin. These patients had not taken suggested vitamin D3 supplementations before. Methods. Patients with diagnosed hypovitaminosis D have been receiving oral doses of cholecalciferol - 1000 IU/day for a period of not less than six weeks. Then their serum levels of 25OHD were checked again. All of them have been treated with vitamin D product under the trade name Vigantoletten tablets 1000 IU. Results. 47 patients (approx. 45%) did not have a sufficiently effective cholecalciferol substitution despite supplementation conducted in accordance with the recommendations, and only 42 people (40%) had serum 25OHD concentrations exceeding 35 ng/ml. Analysis of the body weight, body surface area and increments in serum 25OHD levels relationships do not allow for accurate prediction of oral cholecalciferol supplementation results. Conclusions. 1. The recommended prophylactic doses of vitamin D3 do not provide for obtaining the desired plasma 25OHD levels in all subjects applying the recommended vitamin D3 supplementation. 2. In 45% of patients with diagnosed vitamin D deficiency, the 25OHD serum levels have not been normalized despite taking recommended prophylactic doses of vitamin D3. 3. It should be taken under consideration individualization of vitamin D supplementation and expanding the list of indications to (at least) serum levels of 25OHD checking prior to start of vitamin D supplementation.
- Publication
Pediatric Endocrinology / Endokrynologia Pediatryczna, 2015, Vol 14, Issue 1, p11
- ISSN
1730-0282
- Publication type
Academic Journal
- DOI
10.18544/ep-01.14.01.1506