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- Title
تهیه نانوذرات اکسید آهن پوشیده با امگ ا- 3 و تأثیر آن بر عملکرد کبدي، کلیوي و طحالی در موش صحرایی: یک مطالعه تجربی
- Authors
Tamjid, M.; Mahmoudi, F.; Abdolmaleki, A.; Mirzaee, Sh.
- Abstract
Background and Objectives: Due to its unique properties, iron oxide nanoparticles have many applications in medicine. The aim of this study was to prepare omega-3 coated iron oxide nanoparticles and investigate their effect on liver and kidney, and spleen function in rats. Materials and Methods: In this experimental study, 30 Wistar rats were randomly divided into three groups including control group (receiving physiology serum as drug solvent), experimental groups 1 and 2 treated with omega-3 coated iron oxide nanoparticles with doses of 10 and 30 mg/kg, respectively. After one week of drug treatment, blood sampling and tissue sampling of liver, kidney, and spleen were performed. One-way analysis of variance, Tukey's post hoc, Levene, and non-parametric Kolmogorov-Smirnov tests were used for data analysis. Results: Injection of nanoparticles at a dose of 10 mg/kg did not show a significant change in blood urea and AST (Aspartate Transaminase) factors compared to the control group (p=0.042). However, at a dose of 30 mg/kg, creatinine and ALT (Alanine Transaminase) blood factors increased significantly compared to the control group (p =0.038). Histopathological examination of liver, kidney, and spleen tissue samples of the treated groups did not show any tissue disorders compared to the control group. Conclusion: The results showed that omega-3 coated iron oxide nanoparticles at low doses had no toxic effects on the studied tissues and did not disrupt blood factors. Therefore, it can be further evaluated as an adjunct in the treatment of cancer cells as well as drug carriers.
- Publication
Journal of Rafsanjan University of Medical Sciences, 2021, Vol 20, Issue 8, p879
- ISSN
1735-3165
- Publication type
Academic Journal