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- Title
PERSPECTIVES ON THE BIOMEDICAL USE OF THE FLAVONOL QUERCETIN AND ITS DERIVATIVES: A REVIEW ON REPORTED EFFECTS AND GAPS BASED ON BIOINFORMATICS.
- Authors
García, Lina M.; Morantes-Ariza, Carlos F.; Rojas-Rodríguez, Felipe; Molina, Diana; Ramírez, Daniela Maria; Arias, Alexandra; Cardona, David; Luna, Nicolás; Torres, Simón; Velandia, Valeria; Londoño, Manuela; Riveros, Andre J.
- Abstract
Flavonoids are among the secondary plant metabolites most intensely studied over the last decades. The reason for this surge in interest come from the evidence supporting multiple effects on human and animal health, particularly based on antioxidant functions. Importantly, among flavonoids, Quercetin, a naturally occurring molecule originally derived from the tree Quercus has been at the core of research. Quercetin has functions ranging from antioxidant to antiapoptotic, cell growth regulator, antidiabetics and anti-inflammatory. Following these findings, synthetic and naturally occurring Quercetin derivatives have received increasing attention. Focusing on derivatives enables an understanding of the pathways that underlie the activity of each molecule as each variant may target specific points along the pathway. In turn, understanding the structural and functional relationships among molecules will enable better targeting in biomedicine. Thus, we aimed to analyze the chemical structural similarity profiles among Quercetin and its derivatives, further identifying the biological functions and suggesting targets for research based on a literature review. As a result of these approaches, we built a similarity tree based on molecular structure and 2,326 traits extracted from NCBI through ChemmineR package for R. Following the review, we identified major biological activities and the main physiological systems and organs targeted by each derivative of Quercetin. Biological activities for each molecule were selected following a bibliographic search using the databases Web of Science, Scopus and PubMed. The complete records and cited references of the 38,185 identified manuscripts were imported into VOSviewer for the bibliometric analysis. We found that R-O-R' and R-O-S functional groups played a major role in the determination of the similarity profiles. Moreover, we found a large variation in the number of studies that focus on all molecules. The most studied systems were the nervous, liver, cardiac and immune, whereas the most studied functions were antioxidant, antibacterian, anti-inflammatory, antiviral, antineoplasic, and the inhibition of tyrosine kinase, MAO and TNF alpha. Based on these results we point at least 11 gaps of functions based on similarity and further discuss new targets.
- Publication
Journal of Research of the University of Quindio / Revista de Investigaciones Universidad del Quindio, 2019, Vol 31, p262
- ISSN
1794-631X
- Publication type
Academic Journal