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- Title
Search of new inhibitors of protein kinase CK2 among 2-pyridone derivatives.
- Authors
Ostrynska, O. V.; Ukrainets, I. V.; Sidorenko, L. V.; Starosyla, Yu. A.; Protopopov, M. V.; Kukharenko, O. P.; Bdzhola, V. G.; Yarmoluk, S. M.
- Abstract
The search of inhibitors of protein kinase CK2 among 2-pyridone derivatives via receptor-based virtual screening and biochemical tests in vitro was carried out. It was found that one inhibitor from 15 selected compoundshave IC50=8.3 µM. The binding mode of this ligand with amino acid residue of ATP-acceptor site of protein kinase CK2 has been proposed.
- Publication
Ukrainica Bioorganica Acta, 2015, Vol 13, Issue 2, p17
- ISSN
1814-9758
- Publication type
Academic Journal