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- Title
EVALUATION OF THE ANTIMICROBIAL AND ANTI-BIOFILM ACTIVITY OF SOME 4,2 AND 5,2 BISTHIAZOLES DERIVATIVES.
- Authors
ARANICIU, C.; MARUTESCU, L.; ONIGA, S.; ONIGA, O.; CHIFIRIUC, M. C.; PALAGE, M.
- Abstract
Due to the emergence of antimicrobial resistance, new antibiotics or anti-pathogenic drugs are strongly needed. In this context, 15 new 4,2 and 5,2 bisthiazole derivatives were investigated in order to determine their antimicrobial activity and influence on microbial biofilm development and subsequent inert substratum colonization. The obtained compounds were tested on five bacterial strains and one fungal strain. The antimicrobial activity was assessed by using both qualitative (an adapted disk diffusion technique) and quantitative assays (broth micro-dilution and biofilm microtiter methods). The compounds showed a low to good antimicrobial activity especially against Escherichia coli ATCC 25922. A moderate anti-biofilm effect was exhibited against Pseudomonas aeruginosa ATCC 27857 and E. coli ATCC 25922 strains. Five of the tested compounds exhibited good antibacterial and anti-biofilm activities against E. coli ATCC 25922.
- Publication
Digest Journal of Nanomaterials & Biostructures (DJNB), 2014, Vol 9, Issue 1, p123
- ISSN
1842-3582
- Publication type
Academic Journal