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- Title
Lipid lowering effect of dietary supplementation with Nigella sativa L. in hyperlipidemic rabbits.
- Authors
Ebrahimzadeh-Attary, Vahideh; Pourghassem-Gargari, Bahram; Rafraf, Maryam; Gorbani, Abolfazl
- Abstract
The seeds of Nigella sativa L. (black seed) have many nutritional and pharmaceutical benefits, so the present study was aimed to examine the hypolipidemic effect of dietary black seed in rabbits. New Zealand male rabbits were fed a 0.5 % cholesterol diet for 1 month and then were randomly assigned to two groups; the control group received the previous hypercholesterolemic diet and the black seed group were fed 7.5 g/kg b.w/day crushed black seed + 0.5% cholesterol diet, each for 2 months. Fasting blood samples were obtained at baseline, after hyperlipidemia, 1 month and 2 months of treatment to determine the levels of serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL.C), high density lipoprotein cholesterol (HDL.C) and the coronary heart disease's risk ratio, TC/HDL.C and LDL.C/HDL.C. The concentrations of serum TC, TG, LDL.C and TC/HDL.C were significantly lower in black seed group, compared to control group at the end of study (P<0.05). In conclusion, these findings demonstrate that dietary black seed can favorably decrease serum lipid profile in hyperlipidemic rabbits, so may be developed as a useful therapy for hyperlipidemia.
- Publication
Journal of Medicinal Food Plants, 2009, Vol 1, Issue 2, p80
- ISSN
1947-3710
- Publication type
Academic Journal