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- Title
Quercetin Loaded Nano-Lipidic Carriers Exerts Diethylnitrosamine Induced Hepatic Cancer via Attenuation of Cellular Inflammation and Cell Proliferation.
- Authors
Chauhan, Deeksha; Bhatt, Prakash Chandra; Kumar, Vikas
- Abstract
Background/Aims Hepatocellular carcinoma (HCC) is the 3rd most common cause of mortality, among all types of cancer. Clinical fraternity suggest the liver transplantation and surgical resection are the only option for the HCC, both treatment having limitations either due to late detection or patient condition. Targeted plant-based drug are appropriate resources for anticancer therapy. In this study, we examined the anticancer effect of quercetin loaded nano-lipidic carriers (QE-NLCs) against diethylnitrosamine (DEN) induced HCC via attenuation of cellular inflammation and cell proliferation. Methods DEN (200 mg/kg) intraperitoneal injection of was used for induction the HCC and rats were orally received the QE-NLCs. The body weight, serum biomarkers, morphological and histopathological evaluation were performed at end of the experimental study. The inflammatory, pro-inflammatory, cancer preventive agent status, antioxidant enzymes and apoptosis marker were appraised to examine the possible mechanism. Results QE-NLCs reduced the hepatic nodules (83%), with significantly (p<0.001) increased body weight (46.7%); altered the level of hepatic marker viz., alpha-fetoprotein (84.5%), aspartate aminotransferase (56.7%), alanine aminotransferase (59.8%), alkaline phosphatase (63.8%); non-hepatic parameter such as GGT (56.8%), albumin (54.5%), total protein (47.6%), blood urea nitrogen (57.8%), direct bilirubin (56.4%), total bilirubin (43.8%); antioxidant parameter including LPO (65.4%), GSH (53.4%), CAT (48.3%), SOD (53.8%), GST (50.4%), GPx (58.3%); apoptosis marker like caspase-3 (43.5%) and caspase-9 (50.4%), respectively. QE-NLCs significantly (p<0.001) down-regulated the pro-inflammatory cytokines such as tumor necrosis factor-α (54.5%), interleukin (IL)-6 (48.3%), IL-1β (52.5%); inflammatory mediators like COX-2 (43.5%), PGE2 (43.5%), iNOS (45.6%), and NF-κB (56.6%) as compared to DEN control. Conclusions Furthermore, QE-NLCs proved its chemoprotective effect against DEN induced HCC via attenuation of cellular inflammation and cell proliferation.
- Publication
Gut & Liver, 2019, Vol 13, Issue 6(suppl. 1), p68
- ISSN
1976-2283
- Publication type
Academic Journal