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- Title
PROTECTIVE INTERVENTION OF SAMBUCUS NIGRA POLYPHENOLS IN THE DIABETIC HEART.
- Authors
Ciocoiu, Manuela; Badescu, L.; Badulescu, Oana; Tutunaru, Dana; Badescu, Magda
- Abstract
The present study focuses on the way in which natural polyphenols extracted from the Sambucus nigra fruits influence the oxidative stress from the experimental diabetes, as well as improving the state of the cardiovascular lesions. Diabetes was induced by streptozotocin 55 mg/Kg body mass. The glycosylated haemoglobin values in the diabetic group are very high, as compared to the group protected by elder fruit extract where these values were significantly low. Due to the polyphenolic protection, the serum activity of glutathione peroxidase is more intense for the diabetic rats treated with natural polyphenols as compared to the diabetic rats. The obtained results highlight a significant improvement (p<0.001) in the antioxidative capacity of the serum in diabetic rats treated with natural polyphenols, bringing back to normal the concentration of reduced glutathione, as well as an important decrease in the serum concentration of malondialdehyde, thus proving an important decrease of the lipid peroxides in serum. After the administration of polyphenols, the values of IL-1b significantly decreased. The natural polyphenols compounds do reduce the lipids peroxides, do neutralize the lipid peroxil radicals, and by this do prevent the cardiovascular long term consequences of the experimentally induced diabetes mellitus.
- Publication
Annals of the Romanian Society for Cell Biology, 2012, Vol 17, Issue 1, p312
- ISSN
2067-3019
- Publication type
Academic Journal