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- Title
COMPRESSION BEHAVIOUR OF KETOPROFEN AMORPHOUS FORMS.
- Authors
Malaj, Ledjan; Hoti, Ela; Gashi, Zehadin; di Martino, Piera
- Abstract
In the present study, both the compression and the densification behaviours of ketoprofen-polyvinylpyrrolidone co-precipitates along with their physical mixtures (PMs) were investigated. Coprecipitates were obtained using solvent evaporation method under reduced pressure at a temperature of 40 °C. Solids were recovered, grounded in a mortar (the 0-100 mm-sieved fraction was recovered) and stored in a desiccator with the P2O5 serving as desiccant. PMs of the two compounds were obtained in the same proportions by mixing them in a V-shaped mixer. Homogeneity was reached as a result of the PMs compounds mixed in a V-shaped mixer. The compression study was performed on a high tech mini rotary press equipped with a computerized control system to detect and analyze force-signals (pressing force and ejection force) and with ten flat 11.28 mm-diameter punches. The densification behaviour of powders was studied using an instrumented Frogerais OA single punch tablet machine. Characterized by an increase in plastic deformability, which, inversely to PVP, is not accompanied by an elastic component, the Ket-PVP coprecipitates showed a very different mechanism. Amorphous ketoprofen form showed a different densification mechanism compared to crystalline ketoprofen, as a result of a fragmentation tendency loss and a plastic deformability acquirement.
- Publication
Albanian Journal of Natural & Technical Sciences, 2010, Vol 27, Issue 1, p169
- ISSN
2074-0867
- Publication type
Academic Journal