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- Title
Extraction Technology and Anti-depression Activity of Saponins from Lilium brownii.
- Authors
WANG, Ying
- Abstract
[Objective] To investigate the extraction technology of saponins from lily (Lilium brownii) and the anti-depressant activity of saponins . [Methods] The saponins extraction was optimized by an L9 (3) orthogonal design with the volume fraction of ethanol, amount of etha-nol, extraction time as factors, using saponins extraction rate as index. Kunming mice tested were divided into normal control group (constant volume of normal saline), fluoxetine group (0.004 g/kg) and high-dose, medium-dose and low-dose lily saponins groups (0.1, 0.05 and 0. 025 g/kg). The duration of immobility within 4 min were recorded in tail suspension test and forced swimming test. Body temperatures of mice were recorded at 4 h after modeling in reserpine-induced hypothermia test. [Results] The optimal extraction technology of lily saponins was as follows; extraction with 70% ethanol once, lasting for 3 h.compared with normal control group, the duration of immobility within 4 min in tail suspension test and forced swimming test were decreased in medium-dose and low-dose lily saponins groups (P<0.05); the body temperature of mice was decreased at 4 h after modeling (P<0.05). [Conclusions] Lily saponins have certain anti-depressant activity in mice.
- Publication
Medicinal Plant, 2014, Vol 5, Issue 6, p46
- ISSN
2152-3924
- Publication type
Academic Journal