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- Title
Effects of Aerobic Exercise in Alleviating Depressive Symptoms of Cerebral Ischemic Rats with Sedentary Behavior by Improving Inflammatory Microenvironment in Hippocampus.
- Authors
Qiang REN; Hui NIE
- Abstract
[Objectives] To explore the role and molecular mechanisms of aerobic exercise in post-stroke depression. [Methods] Wistar rats were randomly divided into sham, sedentary' and aerobic exercise (Ex) groups. The rats in sedentary and Ex groups received middle cerebral artery occlusion (MCAO) surgery. Aerobic exercise was performed 24 h after MCAO for four weeks in Ex group. The sucrose preference test (SPT), open field test (OFT), tail suspension test (TST) was performed, respectively. The levels of IL-lß, IL-6, TNF-a were detected by ELISA. [Results] Aerobic exercise successfully prevented depression-like symptom induced by ischemic stroke w'ith sedentary behavior as indicated by significant increase in sucrose preference (P <0.01) during SPT and decrease in immobility time (P <0. 01) during FST and TST. Aerobic exercise significantly reduced the high levels of IL-lß, IL-6, TNF-a induced by ischemic stroke and sedentary' behavior in the ischemic hippocampus (P <0.05). [Conclusions] Aerobic exercise after ischemic stroke can reverse depression and improve the inflammatory microenvironment in the hippocampus.
- Publication
Medicinal Plant, 2022, Vol 13, Issue 4, p74
- ISSN
2152-3924
- Publication type
Academic Journal
- DOI
10.19600/j.cnki.issn2152-3924.2022.04.017