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- Title
Association between stat3 expression and Gamma Knife radiosurgery on the post-operative cavity after cerebral metastasis resection.
- Authors
Bucpapaj, Roada; Galuppo, Marco; Ammendola, Serena; Bulgarelli, Giorgia; Longhi, Michele; Zivelonghi, Emanuele; D’Amico, Anna; Ricciardi, Giuseppe Kenneth; Polloniato, Paolo; Basso, Enrico; Sala, Francesco; Barresi, Valeria; Pinna, Giampietro; Nicolato, Antonio
- Abstract
STAT proteins (Signal Transducers and Activators of Transcription) are heterogeneous transcription factors that are known to be critically involved in cellular proliferation, growth and apoptosis process. STAT3 phosphorylated status strongly correlates also with metastasis process promotion. It represents a negative prognostic predictor both for the recurrence of tumor lesions and for their progression after surgical treatment. Considering that the addition of stereotactic radiosurgery to the surgical resection of brain metastases decreases local relapse and death from neurologic cause, we investigate the correlation between STAT3 primary tumor expression and post-resection cavity stereotactic radiosurgery response in brain metastasis in terms of local relapse, distant brain control, overall survival and local radiosurgery side effects. Data of all patients who underwent post-operative stereotactic radiosurgery to the resection cavity following excision of brain metastases at our Department of Neurosurgery of Verona between 2009 and 2019 were reviewed. All patients with GTR (Gross Total Resection) of single brain metastasis from variable primitive tumor and no previous radiant adjuvant therapy were included in our study. A total of 82 patients (42 women and 40 men) were enrolled. Twenty-two brain metastases cavities were cerebellar, while sixty supratentorial. The site of the primitive tumor was: 32 cases of lung cancer, 14 of breast cancer, 14 of gastro-enteric cancer, 9 of renal cancer, 6 of ovarian cancer, 4 of melanoma, 2 of uterus cancer, 1 of not better specified cancer. About stereotactic radiosurgery treatment parameters, mean volume treated was 7,82 cc (1,01-22,6); mean prescription dose was 17,52 Gy (13,0-22,0) with a 50% prescription isodose and a maximal prescription dose of 35,08 Gy, (26,0-44,0); mean shot number was 11,9 (1-29). Patients were divided into two groups based on histological examination and expression of STAT3 activated status in the primitive tumor tissue. The response to the treatment of the two different groups based on outcomes for local relapse, distant brain control, overall survival and local radio surgery side effects was analyzed and compared.
- Publication
Journal of Radiosurgery & SBRT, 2022, Vol 8, p95
- ISSN
2156-4639
- Publication type
Academic Journal