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- Title
Role of adenosine in signal transmission of tubuloglomerular feedback.
- Authors
Osswal, Hartmut; Hermes, Hubert H.; Nabakowski, Gerhard
- Abstract
The present study has developed a new hypothesis for the regulation of renal hemodynamics based on the theory of a metabolic control of local blood flow. Adenosine has been proposed as the mediator of tubuloglomerular feedback. We have reported on the renal effects of adenosine, the renal tissue levels of adenosine in relation to those of ATP, and the effects of adenosine synergistic substances (dipyridamole, erythrohydroxynonyladenine) and adenosine antagonistic substances (theophylline, adenosine deaminase) on the tubuloglomerular feedback response of the nephron. A hypothetic model has been presented that incorporates adenosine as a mediator in the signal transmission of the tubuloglomerular feedback mechanism.
- Publication
Kidney International Supplement, 1982, Issue 12, pS-136
- ISSN
0098-6577
- Publication type
Academic Journal
- DOI
10.1111/1523-1755.ep17670400